A fast-evolving human NPAS3 enhancer gained reporter expression in the developing forebrain of transgenic mice
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منابع مشابه
A fast-evolving human NPAS3 enhancer gained reporter expression in the developing forebrain of transgenic mice.
The developmental brain gene NPAS3 stands out as a hot spot in human evolution because it contains the largest number of human-specific, fast-evolving, conserved, non-coding elements. In this paper we studied 2xHAR142, one of these elements that is located in the fifth intron of NPAS3. Using transgenic mice, we show that the mouse and chimp 2xHAR142 orthologues behave as transcriptional enhance...
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ژورنال
عنوان ژورنال: Philosophical Transactions of the Royal Society B: Biological Sciences
سال: 2013
ISSN: 0962-8436,1471-2970
DOI: 10.1098/rstb.2013.0019